Sulfation of Therapeutic Proteins in Plants


The present invention relates to the use of Tyrosylprotein Sulfotransferase (TPST) in plant-based protein expression systems to ensure appropriate sulfation patterns of therapeutic proteins. The offered technology enables engineering of plants in such a way that they can sulfate proteins like mammals, which will increase the versatility of plant-based protein production systems.

Category

Life sciences

Projectnumber

P1405101

Patent Status

EP application filed on 20th of April 2015

Description

The present invention relates to the use of Tyrosylprotein Sulfotransferase (TPST) in plant-based protein expression systems to ensure appropriate sulfation patterns of therapeutic proteins. The offered technology enables engineering of plants in such a way that they can sulfate proteins like mammals, which will increase the versatility of plant-based protein production Systems

Benefits

  • Native-like sulfation of proteins in plant-based pro-tein expression Systems
  • Improving functionality of therapeutic Proteins
  • Comparable sulfation pattern as in CHO cells
  • Compatibility with other advantages of plant-based expression platforms (glycan homogeneity, flexibility, production speed, ease of large-scale production)

Cooperation Options

  • License Agreement
  • Collaboration
  • Purchase

Contact

Dipl.-Ing. Dr. Manfred Lampl
Schutzrechtsmanagement
+ 43 1 501 75 - 553